The Background History of Laminine™

Laminine research confirms the fact that this formula can produce a wide range of important health benefits. Some of the most important ones include:

Maintaining healthy cortisol levels for stress relief Regulation of serotonin production Improved quality of sleep Moderation of the stress response Healthier skin through improved collagen production Improved stamina and higher levels of energy Increased libido Enhanced muscle tone Improved brain function, focus and memory Emotional balance An overall sensation of wellbeing

According to the studies conducted by the team of Dr. Alex Martin, Lifepharm Laminine can reduce cortisol production by nearly 50 percent. This is one of the keys to keeping chronic stress under control and achieving emotional balance.

Researchers also found out that FGF plays an important role in the fertilized avian egg, which translates in a vast range of health benefits. FGF directs the amino acids and peptides to the right parts and cells of the body. It plays a vitally important role in "telling" cells what to do with these nutrients and how to utilize them properly. FGF plays another important role - it nurtures the stem cells of the body itself. FGF is a unique extract that is not present in other amino acid formulas.

Brief overview of Laminine History
In the late 1920s, Canadian Dr. John R. Davidson discovered an extract derived from the tissue in fertilized hen eggs at a precise point during the incubation period. It wasn't until almost 50 years later that the pursuit of fertilized egg extract was revived by Norway's foremost expert on egg research, Dr. Bjodne Eskeland.

Dr. Eskeland hypothesized that partially incubated, fertilized hen eggs contained a unique combination of amino acids, peptides, and protein fractions that could help provide an incredible array of health benefits upon consumption. It was found that on the ninth day of fertilization these partially incubated, fertilized eggs theoretically contain all the nutrients required to start a new life. This includes vitamins, minerals and proteins, as well as important defense factors, growth factors and hormones.
It is during this very precise moment on the ninth day that this highly potent tissue is extracted.

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WHAT IS Laminine™? 

When we started down the path of looking to provide its customers a solid, proven nutritional supplement to aid the brain in regulating the body and build a stronger body, we searched for an amino acid and oligopeptide combination which had all the required nourishment for the task at hand. 

We found numerous studies for the cause and effect of individual amino acids, peptides and hormones, not to mention an equal number of products touting high dosages of one over another as beneficial for consumption. What was not clear was how many companies had developed and proven the right “combination” of amino acids, peptides, and growth factors required? It didn’t surprise us to find there were none. So we embarked on our own research project. We looked for a balanced amino acid/peptide blend in nature, which could meet our needs with minimal additions.

That is when we discovered that in 1929 a Canadian doctor, Dr. John Ralston Davison, theorized that an injected extract from fertilized hen eggs could be helpful for a number of his cancer patients. In fact, he spent well over a decade developing and researching his theory. However, when Dr. Davidson passed away in 1943, his research on fertilized hen eggs quickly and quietly came to a halt and was lost.

HOW DOES Laminine™ WORK & WHAT'S IN IT?

What does Opt9 Contain?

OPT9 contains a natural combination of nutrients, including amino acids, glycopeptides, and oligopeptides that come from fertilized eggs, isolated plant proteins, and marine elements that work together to form a super food for the mind and body.

The Health Benefits of Laminine™

Laminine™ has a variety of potential health benefits, including, strength, stamina, increased libido, and sense of well being. 
These various effects may all be related to the significant reduction of the stress hormone cortisol (by about 50 percent) after the ingestion of Laminine™.

What exactly is PESE, and how much is known about its benefits?

Proto Embryonic Stage Extract is the name we have given the ingredient in Laminine™ that is derived from the partially incubated 
(9 days) fertilized hen eggs. PESE contains the most potent and balanced combination of not only amino acids, but also other known 
(and unknown) factors such as Fibroblast Growth Factor. We believe amino acids derived from such fluids combined with the growth factors are  able to enhance brain function because they are “precisely” engineered to support the most complex stage of birth of a living creature, the beginning. This beginning is the most critical stage in our development just like the take off is the most complex function in flying an airplane, or the foundation in construction is the most essential function in the life of a building.

The health benefits of the hen egg have been known for centuries. Recently, further investigation of the mechanism of the development of an embryo in an egg during incubation revealed the scientific equivalent of the “miracle of life”. 
The potency of the nutrients available to the embryo at the latter stage of development stage has always been assumed to be high, but it was only recently that the chemical structure of the original egg solids for these critical stages was obtained. During this stage oligopeptides with small molecular weights were identified. These short chains of amino acids are able to cross the digestive barrier without breaking down or changing the ratios and proportions. Peptides are far more potent than other neurotransmitters, requiring only small amounts to produce a profound effect.

Additionally, the uptake of the Fibroblast Growth Factor (FGF) (present in PESE) by the embryo sharply increases and the FGF present have been isolated through a patented process precisely at the right stage of incubation, extracted and freeze dried to bring the “miracle of life” benefits to humans.

Extracting PESE before the peptides and FGF are “used up” to build organs and bones, allows us to provide this building, repairing, maintenance mechanism of perfectly balanced amino acids, peptides and growth factors to humans. While virtually unknown in the United States until very recently, PESE has been marketed successfully as a nutritional supplement in Scandinavia for many years.

How is FGF helpful to humans?

The precise blend of oligopeptides may be seen as building blocks, without a bridge, or a director.            
The role of such a director is fulfilled by a growth factor known as the Fibroblast Growth Factor, or FGF. 
FGF is prolific in PESE, as well as in the human placenta. A detailed day-by-day study was performed in 1988. 
Discovered only in the seventies, and also a peptide, this FGF is critical in the development of embryos, including humans. 
However, it is not found to be circulating in the human adult bodies. FGF is responsible for building the linings in the blood vessels, creating the infrastructure for the nutrients to flow to critical areas of the brain and organs. Research credits FGF with the potential to directly affect many neuro disorders because of clear results of the ability of FGF to affect the growth of neurites. Neurites are signal senders (Axons) and signal receivers (dendrites) attached to the brain neurons.

Research has also shown clearly that new cell cultures show a dramatic increase in peptide and amino acid uptake in the presence of FGF. This result gives credence to the hypothesis that embryonic growth is influenced by a very precise mechanism, which combines unique combinations of amino acids, peptides and FGF.

Since FGF is not circulating in adults, multiple research projects on the effects of FGF serums to cure neuro disorders have been carried out. Fundamental to the research is the fact discovered by Altman, J. in 1962 that neural STEM cells are formed by the body in response to abnormalities, and are resident in certain zones of the brain. The brain is therefore ready to repair the damage, and these cells have shown to differentiate into a wide range of neurons. Neurons derived from such neural stem cells are capable of migrating to various regions of the Central Nervous System.

Use of vegetable proteins

Vegetable protein has an essential amino acid profile, which is very close to that of the ideal protein for human nutrition (FAO/WHO 1985 and 2002). For Laminine™, a patented process further isolates these protein’s to eliminate the compounds, which neutralize the benefits of the essential amino acids.              
The result is an ingredient, which is high in Glutamic acid, (further enhancing the cognitive function of the brain), branched chain amino acids (to counter insomnia), Lysine (to control release of serotonin, controlling moods) and Arginine (promoting Nitric Oxide and growth hormone formation). These specially isolated proteins’s therefore adds a synergistically potent composition to enhance brain activity.

Use of Marine Proteins

The high levels of Glycine in the specially extracted marine protein used in Laminine™, combined with a significant amount of hydroxyproline to stabilize the glycine, makes it a primary candidate for a terrific brain food. By itself, Glycine is a neurotransmitter, primarily utilized by the brain to control glutamate levels. As a combination within OPT9, it becomes a powerful force to enhance memory function in the brain.

AMINO ACIDS AND THEIR ROLES

Amino acids are critical to life, and have many functions in metabolism. One particularly important function is as the building blocks of proteins, which are linear (straight) chains of amino acids. Laminine™’s unique blend of ingredients combines to produce a complete chain of 20 amino acids. The following is a list of those amino acids and their potential benefits. Amino acids are organic compounds that combine to form proteins. When proteins are digested, amino acids are left. The human body requires a number of amino acids to grow and breakdown food and is a very important part of nutrition. A complete balance of amino are contained in Laminine™ and include:

Glycine and glutamine are precursors of nucleotides. Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA.

These building blocks of proteins perform various vital roles in the body and help us to remain healthy in many ways.

· Antioxidants helping with combating free radicals and environmental toxins including ultraviolet light, radiation, cigarette smoking, 
and air pollution.
· Benefits in treating some respiratory conditions, such as bronchitis and COPD. Angina, Chronic bronchitis and Chronic Obstructive Pulmonary Disease (COPD), Influenza, Acute Respiratory Distress Syndrome (ARDS), HIV/AIDS.
· Reducing symptoms of asthma, cystic fibrosis, and emphysema.
· Helping to Improve or Preventing colon cancer.
· Helping to Improve or Preventing cataracts and macular degeneration.
· Helping increase HDL “good” cholesterol.
· Helping increase fertility when taken along with fertility drugs in people with polycystic ovary disease.
· Helping improve outcome in children with advanced cerebral adrenoleukodystrophy, a type of leukemia.
· Helping treat cocaine addiction, schizophrenia, and gambling addictions.
· Reducing lung cancer risk among smokers.
· Decrease Cell oxidation.
· Enhances neurotransmitters in the brain.
· Assist in the formation of tooth enamel.
· Blood coagulation regulation.
· Immune response.
· Increased memory function, cognition, and voluntary movement and learning ability.
· Aid in the elimination of toxic ammonia in the form of nitrogen from the body.
· Improve hair and skin.
· Fight insomnia.
· Increase energy and endurance.
· Regulation of blood pressure under stress.
· Controls release of serotonin and mood improvement.
· Increased vasodilatation which increases blood flow.
· Humans with atherosclerosis, diabetes or hypertension often show impaired Nitric Oxide pathways.

THE ROLE OF PEPTIDES

Small amino acid chain peptides (such as those contained in Laminine™), commonly known as oligopeptides, are very easily transported through the intestinal, membrane. They are sometimes used as transport mechanisms for drugs.

Peptides are short polymers formed from the linking, in a defined order, of α-amino acids. Proteins are multi peptide chains.

Proteins must be broken down to smaller and smaller peptides, and eventually an amino acid, to perform its functions. 
Dietary intake of peptides and amino acids, which can reach their destination, therefore, can be extremely beneficial.

Peptides are the most abundant compounds in the hypothalamus of the brain, and perform vital functions of communicating sensory impulses to the endocrine system (hormone producing glands).

Understanding the mechanisms of the effect of peptides, and the types of peptides, is a complex field and is being studied extensively.
Unfortunately, these studies are done in isolation and disregard the whole picture of the many complex mechanisms which exist in our body.
Further, these studies are usually focused on a particular amino acid, peptide or other neurotransmitters. While the results identify the final activity with the amino acid/peptide, the mechanism of transport of such critical amino acid/peptides to the final destination is a subject of major arguments.
These arguments cast a shadow on the importance of nutritional supplements. Most doctors will tell you that nutritional supplements “cannot hurt”, but stop short of endorsing them. 
The reason is the lack of evidence that the active ingredients have been formulated in the correct form that can be used by the body.

WHY WE NEED AMINO ACIDS
· Muscle Building & Weight Loss
· Repair of organs
· Hair, Skin & Nails
· Regulate Hormones  
· Immune System
· Memory & Learning
· Testosterone, Estrogen and Progesterone
· Blood, Enzymes & Cholesterol
· Neurotransmitters

SYMPTOMS OF AMINO ACIDS DEFICIENCY
· Mood Swings & Depression
· Anxiety & Nervousness
· Insomnia
· Chronic Fatigue
· Chronic Pain
· Muscular Weakness
· Loss of Lean Body Tissue
· Inability to Lose Body Fat
· Digestive Disorders
· Impaired Healing of Wounds
· Susceptibility to Infection
· Dry, Brittle Hair, Skin & Nails
· Blood Sugar & Blood Pressure

A FEW FACTS ON AMINO ACIDS
· When adequate amounts are not supplied, disease will result
· Whichever amino acid we are lacking in will set the bar for how our bodies use the others
· Our body requires the synergy of all amino acids working together.
· Failure to obtain enough of even 1 of the 8 essential amino acids results in degradation of the body’s proteins.
· The chain is only as strong as its weakest link…the body is only as strong as its weakest amino acid.

AMINO ACIDS & DEPRESSION
· Amino Acids Affect Serotonin Levels
· When they are Low, We can get Depressed
· When they are High, We feel Happier & Content
· 19.2% of US Population is Depressed.
· Depression is the Leading Cause of Disability Worldwide - Not only in Adults but the Number One Disability for Children as well.

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Below is an explanation of why you need Amino Acids, which help to repair and re-balance!

But exactly why are amino acids so important?  
What role do they play in good health? Read on to discover the answers to these questions and more as we take a look at amino acids.

Amino acids are building blocks of protein. But why is protein so important to your body?
Protein makes up a huge proportion of your body weight. This proportion is only surpassed by water.
Protein is prevalent in your hair, muscles, and all of your major organs. 
The protein that we eat each day is broken down into amino acids. The body then will take these amino acids and construct the specific proteins that it needs.

Amino acids are also instrumental in helping to regulate the way the body works. 
This is because enzymes and hormones that regulate body functions, including brain functions, are made up of protein that is derived from amino acids. It is interesting to note that there are only 22 amino acids. However, long chains of these amino acids will combine to make up to 55,000 different proteins.

These proteins are then used to produce all of the enzymes,
hormones and neurotransmitters that will allow for normal function and growth
of all organs of the body. This includes the liver, brain, kidneys, sex organs and heart.

Keep in mind that there are only two types of amino acids. They are the essential amino acids and the non-essential amino acids.

So what is the difference between these two?
The essential amino acids are not manufactured by the body automatically. You will get these amino acids from the food that you eat or the dietary supplements that you take. The non-essential amino acids are manufactured by combining two or more of the essential amino acids. That is why it is very important that your body receives an adequate amount of dietary protein so that it can effectively form all 22 amino acids.

So what happens if you don't get enough protein to form all 22 amino acids?
This can affect almost all parts of your body. You could have emotional problems, developmental problems, weight problems, lingering infections, and the list goes on and on. In fact, without the presence of the 22 amino acids, you will have overall poor health.

But you may be thinking to yourself that it is not a problem because you eat three meals a day. 
But think again. The processed food that we eat these days is sadly lacking in adequate amounts of protein.

So if you want to stay healthy, you need to make sure that you are getting adequate amounts of protein so that it can be transformed into amino acids. If you can't do this with diet alone, it is advisable that you get a good amino acid dietary supplement and take it every day.

The number of people being helped by taking Laminine™ is staggering,
because by having the right building blocks of the body (which are Amino Acids)
on a daily basis, our bodies are able to thrive again, just like in the beginning of life.

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Then came Dr. Bjodne Eskeland

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